Modeling immune behavior for experimentalists.

Dynamical and Mechanistic Reconstructive Approaches of T Lymphocyte Dynamics: Using Visual Modeling Languages to Bridge the Gap between Immunologists, Theoreticians, and Programmers

Dynamic modeling of lymphocyte behavior has primarily been based on populations based differential equations or on cellular agents moving in space and interacting each other. The final steps of this modeling effort are expressed in a code written in a programing language. On account of the complete lack of standardization of the different steps to proceed, we have to deplore poor communication ...

Realistic Modeling for Experimentalists

The Role of Multiscale Protein Dynamics in Antigen Presentation and T Lymphocyte Recognition

T lymphocytes are stimulated when they recognize short peptides bound to class I proteins of the major histocompatibility complex (MHC) protein, as peptide-MHC complexes. Due to the diversity in T-cell receptor (TCR) molecules together with both the peptides and MHC proteins they bind to, it has been difficult to design vaccines and treatments based on these interactions. Machine learning has m...

O1: Modeling of Mesenchymal Stem Cell-Derived Magnetite Nanoparticles for The Rehabilitation of Immune System Function and Reducing Inflammation and Promoting Myelination in the Treatment of MS Disease

By Using the modeling of the mesenchymal (bone marrow) stem cell nanoparticles, the reinstatement of the immune system leads to the treatment of MS, result in the formation of a new immune system for the body by stem cell. The presence of stem cells promotes and strengthens myelination, and that, using simulation and 3D modeling, stem cells can be transmitted correctly to the target and place o...

Mechanistic modeling confronts the complexity of molecular cell biology

Mechanistic modeling has the potential to transform how cell biologists contend with the inescapable complexity of modern biology. I am a physiologist-electrical engineer-systems biologist who has been working at the level of cell biology for the past 24 years. This perspective aims 1) to convey why we build models, 2) to enumerate the major approaches to modeling and their philosophical differ...